Key result
Angiotensin II directly stimulates intestinal epithelial Na+ absorption by increasing apical NHE3 activity and expression through type I receptor activation.
Population
Human intestinal epithelial Caco2BBE cells and mouse jejunum segments
Comparison
Angiotensin II administered basolaterally or… vs Untreated control
Design
Preclinical
Follow-up
Up to 48 hours
Authors
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Should not change practice; hypothesis-generating for intestinal NHE3 in human volume regulation.
p-value: p=<0.05
Angiotensin II directly stimulates intestinal Na+ absorption via NHE3 exocytosis and transcription, providing a mechanism for its role in systemic volume and blood pressure regulation.
Musch et al. (2009) studied In vitro cell culture (Caco2BBE cells) and mouse jejunum. Angiotensin II vs. No addition / baseline was evaluated on Apical NHE3 activity and surface abundance (p=<0.05). Angiotensin II directly stimulates intestinal epithelial Na+ absorption by increasing apical NHE3 activity and expression through type I receptor activation.
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