Why the study?
Anti-inflammatory macrophages facilitate cardiac recovery after myocardial infarction and lactate can influence macrophage phenotype, but the therapeutic role of sodium lactate in MI is unclear.
Does sodium lactate improve cardiac function and promote M2 macrophage polarization in mice after myocardial infarction?
Population
Mice with MI induced by permanent LAD ligation and LPS-stimulated BMDMs
Comparison
Sodium lactate injection vs saline
Design
Preclinical animal and in vitro study
Authors
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Should not yet change practice; leaves open human translation of lactate as post-MI immunomodulator.
Does sodium lactate improve cardiac function and promote M2 macrophage polarization in mice after myocardial infarction?
In a mouse model of myocardial infarction, sodium lactate improved cardiac recovery and remodeling by promoting anti-inflammatory M2 macrophage polarization via the STAT3 pathway.
Zhang et al. (2021) studied this question.
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