September 1, 1996Journal of Pharmaceutical Sciences

Cells Involved in the Capture of Nanoparticles in Hematopoietic Organs

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Population

Preclinical model (bone marrow and spleen)

Design

Preclinical

Authors

SGStéphane GibaudCibles thérapeutiques, formulation et expertise préclinique du médicament MDMarina DemoyCentre National de la Recherche Scientifique JAJ P AndreuxSorbonne Université

Discussion

Member takes

Implication

Nanoparticle uptake by diverse phagocytes in hematopoietic organs requires toxicity monitoring in nanocarrier development; leaves open targeted delivery optimization for clinical use.

Structured PICO

Population

Preclinical model (bone marrow and spleen)

Intervention

Biodegradable poly(isohexyl cyanoacrylate) nanoparticles and nonbiodegradable polystyrene nanoparticles

Outcome

Capture, localization, and retention of nanoparticles in the bone marrow and spleen

Understanding the specific cellular localization of nanoparticles in hematopoietic organs informs both targeted drug delivery and toxicological assessments of nanocarriers.

Cite This Study

Gibaud et al. (1996) studied this question.

synapsesocial.com/papers/6a7f6b75c47bc9bb3efbfbd0 https://doi.org/10.1021/js960032d

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Implication

Nanoparticle uptake by diverse phagocytes in hematopoietic organs requires toxicity monitoring in nanocarrier development; leaves open targeted delivery optimization for clinical use.

Cells Involved in the Capture of Nanoparticles in Hematopoietic Organs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cells Involved in the Capture of Nanoparticles in Hematopoietic Organs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider