Why the study?
Does doxorubicin-loaded nanoparticles reduce the number of metastases in hepatic metastasis-bearing mice compared to free doxorubicin?
Population
Hepatic metastasis-bearing mice (metastases originated from the M 5076 reticulum cell sarcoma)
Comparison
Doxorubicin associated with… vs Free doxorubicin
Design
Preclinical
Authors
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May improve metastasis control with doxorubicin; leaves open translation from murine models to clinical use.
Does doxorubicin-loaded nanoparticles reduce the number of metastases in hepatic metastasis-bearing mice compared to free doxorubicin?
Doxorubicin-loaded nanoparticles demonstrate increased therapeutic efficiency in reducing hepatic metastases in a murine model compared to free doxorubicin.
Chiannilkulchai et al. (1989) studied this question.
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