Why the study?
Does exercise training improve age-associated diastolic dysfunction in rats?
Population
Adult (6-month-old) and old (24-month-old) Fischer 344/BNF1 rats
Comparison
12 weeks of treadmill training vs Normal sedentary cage life
Design
Preclinical
Follow-up
12 weeks
Authors
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Exercise training may reverse age-related diastolic dysfunction in rats; leaves open translation to humans.
Does exercise training improve age-associated diastolic dysfunction in rats?
Exercise training reverses age-associated declines in left ventricular relaxation and ischemia-induced stiffening in a rat model.
Brenner et al. (2001) studied this question.
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