November 4, 2003The Journal of PhysiologyOpen Access

Calmodulin kinase is functionally targeted to the action potential plateau for regulation of L‐type Ca2+ current in rabbit cardiomyocytes

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Population

Rabbit cardiomyocytes

Design

Preclinical

Authors

YWYuejin WuUniversity of Iowa JKJohn KimbroughChildren's Hospital of Philadelphia RCRoger ColbranUniversity of Iowa

Discussion

Member takes

Implication

Hypothesis-generating for voltage-dependent CaMK/CaM effects on ICa-L; clinical translation requires in vivo validation before any practice implications.

Structured PICO

Population

Rabbit cardiomyocytes

Intervention

Voltage clamp conditions modelled upon time and voltage domains relevant to the cardiac action potential

Outcome

L-type Ca2+ current (ICa-L) responses to Ca2+-CaM and CaMKsurrogate

L-type Ca2+ channel regulation by CaMK and Ca2+-CaM is voltage-dependent, with SR Ca2+ release required for responses after strongly positive conditioning pulses.

Cite This Study

Wu et al. (2003) studied this question.

synapsesocial.com/papers/6a7f74e48cb2fb2788a6f5a4 https://doi.org/10.1113/jphysiol.2003.053314

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Implication

Hypothesis-generating for voltage-dependent CaMK/CaM effects on ICa-L; clinical translation requires in vivo validation before any practice implications.

Calmodulin kinase is functionally targeted to the action potential plateau for regulation of L‐type Ca2+ current in rabbit cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calmodulin kinase is functionally targeted to the action potential plateau for regulation of L‐type Ca2+ current in rabbit cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider