Why the study?
While detyrosinated α-tubulin regulates cytoskeletal mechanics in striated muscle, the possible contribution of other α-tubulin modifications, such as acetylation, has not been investigated.
Acetylated α-tubulin increases cytoskeletal stiffness and alters mechanotransduction in striated muscle, highlighting a novel mechanism in muscle mechanobiology.
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No practice change from isolated-cell data; extends detyrosination models of muscle stiffness and leaves open acetylation as a disease target.
Coleman et al. (2021) studied this question.
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