Gonadotropin-stimulated regulation of blood-follicle barrier is mediated by nitric oxide

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Population

Mouse model (preovulatory follicles)

Design

Preclinical

Authors

Discussion

Animal data implicate NO in mouse ovulation; hypothesis-generating and should not yet change clinical practice.

Population

Mouse model (preovulatory follicles)

Intervention

Intravenous injection of sodium nitroprusside, L-arginine, NG-nitro-L-arginine methyl ester, NG-nitro-L-arginine, or human chorionic gonadotropin

Outcome

Intrafollicular influx of inter-alpha-trypsin inhibitor protein (I alpha I) and ovulationsurrogate

Nitric oxide mediates the gonadotropin-stimulated regulation of the blood-follicle barrier and is required for ovulation in mice.

Powers et al. (1995) studied this question.

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