Key Points
- To develop a theoretical model describing resistance vessel myogenic responses to intravascular pressure changes based on active and passive vascular smooth muscle length-tension properties across varying vessel diameters.
- Represented the vessel wall mechanically as a nonlinear passive component in parallel with an active contractile component having sigmoidal tone dependence on wall tension or stress.
- Optimized model parameters using 18 independent experimental datasets derived from pressure or wire myograph systems.
- The model achieved close fits with all 18 experimental datasets when tone depended on circumferential wall tension, with comparable consistency observed for wall stress formulations.
- Model parameters exhibited significant functional trends when evaluated as a function of vessel diameter.
Structured PICO
PPopulation18 independent experimental data sets previously obtained using pressure or wire myograph systems
IInterventionTheoretical model for the myogenic response based on length-tension characteristics of vascular smooth muscle
OOutcomeFit between model predictions and experimental data
A theoretical model successfully describes the myogenic response of resistance vessels, supporting the hypothesis that circumferential wall tension or stress provides the primary signal for myogenic responses.