Comparative Study of Vasodilators in an Animal Model of Chronic Volume Overload Caused by Severe Aortic Regurgitation
Why the study?
Do vasodilators targeting the renin-angiotensin system (captopril, losartan) compared to nifedipine or no treatment improve hemodynamics and slow LV remodeling in a rat model of severe aortic regurgitation?
Population
Male rats with severe aortic regurgitation (AR model), n=9 to 11 animals per group
Comparison
6-month treatment with nifedipine, captopril, or… vs Sham-operated and untreated AR animals
Design
Preclinical
Follow-up
6 months
Authors
Discussion
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Implication
These animal data are hypothesis-generating only; human trials are required before considering RAS inhibitors in severe AR.
Structured PICO
Do vasodilators targeting the renin-angiotensin system (captopril, losartan) compared to nifedipine or no treatment improve hemodynamics and slow LV remodeling in a rat model of severe aortic regurgitation?
P
Population
Male rats with severe aortic regurgitation (AR model), n=9 to 11 animals per group
I
Intervention
6-month treatment with nifedipine, captopril, or losartan
C
Comparator
Sham-operated and untreated AR animals
O
Outcome
Hemodynamics, left ventricular (LV) dilatation, hypertrophy, and loss of functionsurrogate
In a rat model of severe aortic regurgitation, ACE inhibitors and ARBs (captopril, losartan) effectively slowed LV remodeling and preserved function, whereas the calcium channel blocker nifedipine was ineffective.
Cite This Study
Plante et al. (2009) studied this question.