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January 26, 2025Journal of Personalized MedicineOpen Access

Mid-Regional Pro-Adrenomedullin Is Associated with Adverse Cardiovascular Outcomes After Cardiac Surgery

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Why the study?

Tools for risk stratification after cardiovascular interventions are crucial, and the prognostic potential of the biomarker MR-proADM in patients undergoing elective cardiac surgery required investigation.

Does preoperative MR-proADM level predict the composite of hospitalization for heart failure or cardiovascular mortality in patients undergoing elective cardiac surgery?

Population

500 patients undergoing elective cardiac bypass and/or valve surgery

Comparison

MR-proADM risk categories: Low Risk vs Intermediate Risk vs High Risk

Design

Prospective cohort study

Follow-up

5 years

Authors

UBUlrike BaumerNKNiema KazemAHAndreas Hammer

Discussion

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Member takes

Overview

May aid preoperative risk stratification in elective cardiac surgery; hypothesis-generating pending prospective validation.

Structured PICO

Does preoperative MR-proADM level predict the composite of hospitalization for heart failure or cardiovascular mortality in patients undergoing elective cardiac surgery?

P
Population
500 patients undergoing elective cardiac bypass and/or valve surgery, median age 69.8 years, 29.2% female.
I
Intervention
High preoperative Mid-regional pro-adrenomedullin (MR-proADM) levels (> 0.84 nmol/L)
C
Comparator
Low preoperative MR-proADM levels (≤ 0.63 nmol/L)
O
Outcome
Composite of hospitalization for heart failure (HHF) or cardiovascular (CV) mortalitycomposite

Preoperative MR-proADM levels strongly predict 5-year cardiovascular mortality and heart failure hospitalization in patients undergoing elective cardiac surgery.

Cite This Study

Baumer et al. (2025) studied this question.

synapsesocial.com/papers/6a7f8487ebb736a2349075c5https://doi.org/10.3390/jpm15020047
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Midregional Proadrenomedullin for Prediction of Cardiovascular Events in Coronary Artery Disease: Results from the AtheroGene Study2011 · 45 citations
  2. 2Mid-Region Pro-Adrenomedullin Adds Predictive Value to Clinical Predictors and Framingham Risk Score for Long-Term Mortality in Stable Outpatients with Heart Failure2013 · 32 citations
  3. 3Midregional Proadrenomedullin Improves Risk Stratification beyond Surgical Risk Scores in Patients Undergoing Transcatheter Aortic Valve Replacement2015 · 17 citations
  4. 4Prognostic value of mid-regional pro-adrenomedullin in patients with heart failure after an acute myocardial infarction2011 · 85 citations
  5. 5Adrenomedullin Is Associated With Surgical Trauma and Impaired Renal Function in Vascular Surgery Patients2017 · 10 citations