Why the study?
Rotavirus group C causes sporadic cases and outbreaks of gastroenteritis worldwide, but whole-genome sequences of human rotavirus C in public databases are limited.
The acute gastroenteritis outbreak in Hebei, China was caused by a human rotavirus C strain (SJZ217) closely related to Korean and Japanese strains, highlighting regional genetic diversity and possible reassortment.
Alerts clinicians to emerging rotavirus C strains in Asia; leaves open reassortment's role in outbreaks and vaccine impact.
Rotavirus group C is an important cause of sporadic cases and outbreaks of gastroenteritis worldwide. Whole-Genome sequences of human rotavirus C (RVC) in public databases are limited. We performed genome sequencing to analyze a RVC outbreak of acute gastroenteritis in China. Samples from 22 patients were screened for pathogens using RT-PCR, and six samples were positive for rotavirus. Whole-Genome sequencing analysis showed that the outbreak strain SJZ217 belongs to the G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 genotype and shares almost identical genomic sequences with Chungnam isolated in Korea. Phylogenetic analysis revealed strain SJZ217 also fell into a cluster with rotavirus C strains from Japan and Europe. Reassortment in the VP4 fragment was observed. These results helped to understand the genetic diversity and possible spread of RVC strains.
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Wang et al. (2024) studied this question.
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