Why the study?
Acute lung injury associated with acute kidney injury contributes to high mortality.
Does a nicotinic acetylcholine receptor agonist reduce acute lung injury after renal ischemia-reperfusion injury in mice?
Does a nicotinic acetylcholine receptor agonist reduce acute lung injury after renal ischemia-reperfusion injury in mice?
Nicotinic acetylcholine receptor agonists may provide a novel strategy to reduce acute lung injury following acute kidney injury by acting via splenic macrophages.
Acute lung injury associated with acute kidney injury contributes to high mortality. This study showed, for the first time, that nicotinic acetylcholine receptor agonists reduced circulating IL-6 and ALI after renal ischemia-reperfusion injury in mice. These effects of α7nAChR agonist were eliminated in both splenectomized and splenic macrophage (including systemic mononuclear phagocyte)-depleted mice but not alveolar macrophage-depleted mice. nAChR agonist could reduce ALI after AKI via splenic macrophages and provide a novel strategy in AKI.
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Goto et al. (2022) studied this question.
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