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November 14, 2025Scientific ReportsOpen Access

α7 nicotinic acetylcholine receptor agonist attenuates lipopolysaccharide-induced acute kidney injury in mice by reducing CCL2 expression in macrophages

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Authors

SMSayumi MatsuoRURie UniCWChia Hsien Wu

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Overview

Findings reveal α7 nicotinic receptor activation reduces inflammation in acute kidney injury in mice, suggesting new therapeutic routes.

Key Points

  • This research evaluates the protective effects of α7 nicotinic acetylcholine receptor activation on acute kidney injury in mice.
  • Administered lipopolysaccharide (5 mg/kg) to induce acute kidney injury in C57BL/6 mice.
  • Administered GTS-21 (10 mg/kg) post-injury to evaluate its effects on inflammation and kidney protection.
  • Analyzed macrophage response to GTS-21 treatment using RAW 264.7 and U937-derived cells.
  • Conducted RNA sequencing to explore molecular mechanisms involved.
  • GTS-21 administration exhibited anti-inflammatory and renoprotective effects after LPS-induced acute kidney injury.
  • GTS-21 reduced TNF-α levels in macrophages stimulated by LPS.
  • Expression of CCL2 in macrophages plays a role in mediating the protective effects of GTS-21.

Cite This Study

Matsuo et al. (2025) studied this question.

synapsesocial.com/papers/692519acc0ce034ddc3541cfhttps://doi.org/10.1038/s41598-025-23583-x
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Also Consider

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  1. 1α7nAChR agonist GTS‐21 ameliorates sepsis‐induced acute kidney injury via MEF2/PGC‐1α/HO‐1 axis in mice2026
  2. 2GTS-21 attenuates ACE/ACE2 ratio and glycocalyx shedding in lipopolysaccharide-induced acute lung injury by targeting macrophage polarization derived ADAM-172024 · 6 citations
  3. 3Notch signaling pathway mediates anti-inflammatory effects of vagus nerve stimulation during lipopolysaccharide-induced acute kidney injury2026
  4. 4Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-102021 · 22 citations
  5. 5Renoprotective Effects of a Herbal Formulation Against Lipopolysaccharide-Induced Acute Kidney Injury Through Anti-Inflammatory and Antioxidant Activities2026