Why the study?
The precise role of the matricellular protein Angptl4 in the immune cell response during wound healing remains unclear.
Population
Excisional wounds from Angptl4 +/+ and Angptl4 −/− mice
Comparison
Angptl4 −/− vs Angptl4 +/+ and Angptl4 LysM−/−
Design
Preclinical animal and in vitro mechanistic study using flow cytometry and single-cell RNA sequencing
Authors
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Should not yet change practice in nonhealing wounds; leaves open human relevance of the Angptl4-ifi202b monocyte differentiation axis.
Angptl4 regulates monocyte-to-macrophage differentiation during wound healing by modulating ifi202b expression, highlighting a potential mechanism underlying chronic inflammatory wounds.
Wee et al. (2022) studied this question.
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