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This perspective discusses mechanisms explaining why COX-2 selective inhibitors, unlike non-selective NSAIDs such as aspirin, may lead to dysregulation of cardiovascular homeostasis and increased thrombotic events.
Nonsteroidal anti-inflammatory drugs such as aspirin have been used widely for decades but are associated with gastrointestinal side effects. The newer generation of anti-inflammatory drugs, the COX-2 selective inhibitors, do not have gastrointestinal side effects, but at least one of them is reported to lead to an increase in thrombotic events. In his Perspective, Vane discusses new findings ( Cheng et al .) that shed light on why inhibiting COX-2 rather than both COX isoforms may lead to dysregulation of cardiovascular homeostasis.
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John R. Vane (2002) studied this question.
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