November 27, 2012HypertensionOpen Access

Role of KCNQ Channels in Skeletal Muscle Arteries and Periadventitial Vascular Dysfunction

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Population

Spontaneously hypertensive rats and New Zealand obese mice (with Wistar rats as controls)

Comparison

KCNQ channel openers and blockers vs Control conditions / Wistar rats

Design

Preclinical

Authors

OZOlga ZavaritskayaHeidelberg University NZN B Zhuravleva JSJohanna SchleifenbaumBerlin Institute of Health at Charité - Universitätsmedizin Berlin

Discussion

Member takes

Implication

KCNQ openers merit investigation as antihypertensive targets; animal data leave clinical translation open.

Structured PICO

Population

Spontaneously hypertensive rats and New Zealand obese mice (with Wistar rats as controls)

Intervention

KCNQ channel openers and blockers (XE991, linopirdine)

Comparator

Control conditions / Wistar rats

Outcome

Anticontractile effects of perivascular fat and arterial blood pressuresurrogate

KCNQ channel opening represents a potential novel therapeutic target to improve periadventitial vascular dysfunction and reduce blood pressure in hypertension.

Cite This Study

Zavaritskaya et al. (2012) studied this question.

synapsesocial.com/papers/6a7f943b138fa0ec199fe834 https://doi.org/10.1161/hypertensionaha.112.197566

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Role of KCNQ Channels in Skeletal Muscle Arteries and Periadventitial Vascular Dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of KCNQ Channels in Skeletal Muscle Arteries and Periadventitial Vascular Dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider