Why the study?
Does SSRI use increase the risk of gastrointestinal haemorrhage?
Population
1,579 patients. Exclusion criteria included liver disease, portal hypertension, or bleeding diathesis.
Comparison
Selective serotonin reuptake inhibitors use vs No SSRI use (controls)
Design
Case-control
Authors
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Supports vigilance for GIH with SSRI use, particularly alongside NSAIDs or aspirin; leaves open causality in this case-control analysis.
Does SSRI use increase the risk of gastrointestinal haemorrhage?
SSRI use is associated with an increased risk of hospitalization for gastrointestinal haemorrhage, particularly when combined with NSAIDs or aspirin.
Wessinger et al. (2006) studied this question.
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