Key result
IL-1 receptor antagonist matches or outperforms estradiol in reducing fatty streaks in male and female mice.
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BACKGROUND: The cytokines interleukin 1 (IL-1) and tumor necrosis factor (TNF) are secreted by the different cell populations of the vascular wall and have been suggested to promote atherosclerosis. METHODS AND RESULTS: Their respective roles in fatty-streak formation in apolipoprotein E-deficient mice were investigated by use of IL-1 receptor antagonist and TNF binding protein. Estradiol-17beta was used as a positive control. Blocking TNF seemed to be active in female animals but not in males. IL-1 receptor antagonist was as effective as or more effective than estradiol in both sexes. CONCLUSIONS: IL-1 plays a crucial role in the initial step of the atherosclerotic process in this animal model, and blocking the activity of this cytokine should be considered as a therapeutic possibility.
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Maret et al. (1998) studied Atherosclerosis (fatty-streak formation in apolipoprotein E-deficient mice). Interleukin-1 receptor antagonist (IL-1ra) and tumor necrosis factor (TNF) binding protein vs. Estradiol-17beta (positive control) was evaluated on Fatty-streak formation. IL-1 receptor antagonist was as or more effective than estradiol-17beta in reducing fatty-streak formation in both sexes of ApoE-deficient mice, whereas TNF blockade was active only in females.
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