What question did this study set out to answer?

To evaluate the anti-inflammatory efficacy and molecular mechanisms of Artemisia vulgaris methanolic extract and isolated β-caryophyllene oxide against carrageenan-induced paw edema in Wistar rats relative to indometacin.

October 16, 2024Drug and Chemical Toxicology

In vivo and in silico anti-inflammatory activity of Artemisia vulgaris and β-caryophyllene oxide in carrageenan-induced paw edema in Wistar rats

View Full Paper

Ask AI

Bookmark

Authors

GKGandham Sandeep KumarSri Venkateswara University SPSholapuri PayaniSri Venkateswara University KDK. DivyatejaSree Balaji Dental College and Hospital

Discussion

Member takes

Implication

Preclinical study demonstrates reduced inflammation and restored antioxidant levels by Artemisia vulgaris in rat paw edema, suggesting therapeutic potential via pathway inhibition.

Key Points

To evaluate the anti-inflammatory efficacy and molecular mechanisms of Artemisia vulgaris methanolic extract and isolated β-caryophyllene oxide against carrageenan-induced paw edema in Wistar rats relative to indometacin.
Characterized methanolic extract of A. vulgaris using FTIR, LC-MS, and NMR spectral analysis.
Induced paw edema in Wistar rats via sub-plantar injection of 100 µl of 1% carrageenan, followed by quantification of C-reactive protein, lipid peroxidation, and antioxidant enzymes (SOD, CAT, GPx, GR).
Performed in silico molecular docking of plant-derived compounds against targets in inflammatory signaling pathways.
Carrageenan administration markedly elevated C-reactive protein and lipid peroxidation levels while depleting the activities of SOD, CAT, GPx, and GR.
Treatment with A. vulgaris extract and β-caryophyllene oxide dose-dependently restored antioxidant enzyme activities and significantly reduced C-reactive protein and lipid peroxidation.
Computational modeling supported the anti-inflammatory findings by showing direct inhibitory binding of the plant compound to molecular targets mediating inflammatory cascades.

Cite This Study

Kumar et al. (2024) studied this question.

synapsesocial.com/papers/6a7fa1e4044998269cd76ffb https://doi.org/10.1080/01480545.2024.2415349

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study demonstrates reduced inflammation and restored antioxidant levels by Artemisia vulgaris in rat paw edema, suggesting therapeutic potential via pathway inhibition.

In vivo and in silico anti-inflammatory activity of Artemisia vulgaris and β-caryophyllene oxide in carrageenan-induced paw edema in Wistar rats

Discussion

Member takes

Implication

Key Points

Cite This Study

In vivo and in silico anti-inflammatory activity of Artemisia vulgaris and β-caryophyllene oxide in carrageenan-induced paw edema in Wistar rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider