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June 10, 2022European Journal of Anaesthesiology

Prediction of intraoperative hypotension from the linear extrapolation of mean arterial pressure

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Why the study?

The predictive value of changes in MAP alone without reference to absolute MAP is poor for predicting intraoperative hypotension, whereas linear extrapolation of MAP is closer to clinical practice.

Does LepMAP better predict intraoperative hypotension than ΔMAP alone in adult patients undergoing high-risk non-cardiac surgery?

Population

83 adult patients undergoing high risk non-cardiac surgery

Comparison

LepMAP vs ΔMAP alone

Design

Retrospective diagnostic accuracy study at two tertiary University Hospitals

Authors

MJMatthias Jacquet‐LagrèzeUniversité Claude Bernard Lyon 1ALAntoine LarueUniversité Claude Bernard Lyon 1EGEnrique GuilhermeUniversité Claude Bernard Lyon 1

Discussion

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Implication

May support simple MAP-trend alerts for near-term hypotension but should not yet change practice; challenges ΔMAP as HPI benchmark and leaves open ML incremental value.

Structured PICO

Does LepMAP better predict intraoperative hypotension than ΔMAP alone in adult patients undergoing high-risk non-cardiac surgery?

P
Population
83 adult patients undergoing high risk non-cardiac surgery
I
Intervention
Linear extrapolation of mean arterial pressure (LepMAP)
C
Comparator
Changes in mean arterial pressure (ΔMAP) alone
O
Outcome
Prediction of intraoperative hypotension (MAP < 65 mmHg) at 1, 2 and 5 min before its occurrence, measured by ROC AUCsurrogate

A simple linear extrapolation of mean arterial pressure provides reliable real-time prediction of intraoperative hypotension 1 and 2 minutes before its occurrence, outperforming changes in MAP alone.

Cite This Study

Jacquet‐Lagrèze et al. (2022) studied this question.

synapsesocial.com/papers/6a7fa2b6812a481b9a5f257bhttps://doi.org/10.1097/eja.0000000000001693
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intraoperative hypotension and its prediction2019 · 49 citations
  2. 2Ability of an Arterial Waveform Analysis–Derived Hypotension Prediction Index to Predict Future Hypotensive Events in Surgical Patients2019 · 232 citations
  3. 3Relationship between Intraoperative Hypotension, Defined by Either Reduction from Baseline or Absolute Thresholds, and Acute Kidney and Myocardial Injury after Noncardiac Surgery2016 · 1,141 citations
  4. 4Machine-learning Algorithm to Predict Hypotension Based on High-fidelity Arterial Pressure Waveform Analysis2018 · 635 citations
  5. 5Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery2017 · 953 citations