The cellular patterns of middle ear effusions which reveal lymphocytic transformation and macrophage activity, help to explain the basic pathologic condition. This appears to be a typical delayed-type hypersensitivity reaction. The nasal cytogram often contributes to the understanding of the aural pathology. The treatment must be individualized with an effort to find the source of antigenic stimulation causing the response, and, in turns, support the systemic immune system of the patient in definitive ways, as have been suggested.
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Bryan et al. (1976) studied this question.
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