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July 1, 2011RNA BiologyOpen Access

Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model

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NSNatalia N. SinghIowa State UniversityRSRavindra SinghIowa State University

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Singh et al. (2011) studied this question.

synapsesocial.com/papers/6a7fa80a28ca633895ec9e51https://doi.org/10.4161/rna.8.4.16224
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy2009 · 136 citations
  2. 2TIA1 Prevents Skipping of a Critical Exon Associated with Spinal Muscular Atrophy2010 · 82 citations
  3. 3Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing2006 · 228 citations
  4. 4Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.1991 · 206 citations
  5. 5Differential 3′ splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP2009 · 43 citations