Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Transcription pattern of in vivo-labeled late simian virus 40 RNA: equimolar transcription beyond the mRNA 3' terminus1978 · 140 citations
2. 2Splicing precedes polyadenylation during Drosophila E74A transcription.1990 · 76 citations
3. 3Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.1988 · 548 citations
4. 4Multiple factors are required for specific RNA cleavage at a poly(A) addition site.1988 · 106 citations
5. 5Control of <i>doublesex</i> Alternative Splicing by <i>transformer</i> and <i>transformer-2</i> in <i>Drosophila</i>1991 · 349 citations