June 1, 2010HypertensionOpen Access

Low Blood Pressure in Endothelial Cell–Specific Endothelin 1 Knockout Mice

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Why the study?

Does endothelial cell-specific disruption of ET-1 lower blood pressure in mice?

Population

Endothelial cell-specific endothelin 1 knockout mice (ET-1;Tie2-Cre mice) and genetic controls (wild-type…

Comparison

Endothelial cell-specific disruption of… vs Genetic controls

Design

Preclinical

Authors

YKYaz Y. KisanukiThe Ohio State University Wexner Medical Center NENoriaki EmotoVascular / Pulmonary Vascular TOTakashi OhuchiÉcole Nationale de l’Aviation Civile

Discussion

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Implication

Endothelial ET-1 supports basal vascular tone in mice; hypothesis-generating for human hypertension and requires clinical validation.

Structured PICO

Does endothelial cell-specific disruption of ET-1 lower blood pressure in mice?

Population

Endothelial cell-specific endothelin 1 knockout mice (ET-1(flox/flox);Tie2-Cre mice) and genetic controls (wild-type littermates, ET-1(dlox/+) mice)

Intervention

Endothelial cell-specific disruption of endothelin 1 (ET-1)

Comparator

Genetic controls (wild-type littermates and mice systemically heterozygous for the ET-1 null allele)

Outcome

Mean blood pressure and ET-1 peptide levelssurrogate

Endothelial-derived ET-1 plays an essential role in the maintenance of basal vascular tone and blood pressure.

Cite This Study

Kisanuki et al. (2010) studied this question.

synapsesocial.com/papers/6a7fa9f2a97e3300ffd76fa6 https://doi.org/10.1161/hypertensionaha.109.138701

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Low Blood Pressure in Endothelial Cell–Specific Endothelin 1 Knockout Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Low Blood Pressure in Endothelial Cell–Specific Endothelin 1 Knockout Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider