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Does nifekalant injected into the pericardial space reduce transmural dispersion of repolarization in a pig model?
Does nifekalant injected into the pericardial space reduce transmural dispersion of repolarization in a pig model?
Pericardial injection of nifekalant in pigs decreases transmural dispersion of repolarization and increases epicardial effective refractory period, suggesting a potential localized antiarrhythmic strategy.
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Pericardial nifekalant may offer localized antiarrhythmic effects in pigs; leaves open translation to human arrhythmia management.
Transmural dispersion of repolarization (TDR) has been implicated in the onset of ventricular arrhythmia. We investigated the effects of nifekalant (NIF) injected into the pericardial space on TDR and T wave in pig. We injected 50 or 100 mg of NIF into the pericardial space of 11 pigs, and measured the effective refractory period (ERP) between the endocardial and epicardial myocardial cells, as well as QT time and QT peak-end as an index of TDR and T waveforms, respectively. TDR decreased from 56±10 msec to 44±8 msec (P < 0.01), 5.1 min after injection of 100 mg of NIF, although the QTc did not change. At a later time, QTc increased from 457 ± 44 msec before injection to 540±49 msec (P < 0.01) and TDR recovered to the control level. When 50 mg of NIF was injected, the T wave amplitude decreased from 0.433 ±0.301 mV before injection to 0.107±0.192 mV (P < 0.01) at 10 min after injection ; 100 mg of NIF caused the T wave amplitude to decrease more rapidly, reaching a negative value at 4.5 min after injection. Injecting NIF into the pericardial space altered ERP, QT, and T waveform, and also decreased TDR.
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Asano et al. (2007) studied this question.
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