Why the study?
Do beta-receptor antagonists improve ventricular function and symptoms in patients with symptomatic ventricular dysfunction?
Population
Patients with symptomatic ventricular dysfunction (heart failure)
Design
Review
Authors
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Supports low-dose initiation with slow titration in symptomatic ventricular dysfunction; leaves open mortality benefit confirmation in RCTs.
Do beta-receptor antagonists improve ventricular function and symptoms in patients with symptomatic ventricular dysfunction?
Beta-blockers are effective in improving ventricular function and symptoms in patients with symptomatic ventricular dysfunction when initiated at low doses and up-titrated slowly.
Kirkwood F. Adams (1996) studied this question.
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