Why the study?
Fenestration has been reported to enhance hemodynamics in some cases of Fontan circulation, but the indication criteria for fenestration remain under discussion.
Does fenestration improve hemodynamics in a computational model of Fontan circulation?
Does fenestration improve hemodynamics in a computational model of Fontan circulation?
Computational modeling suggests that fenestration effectively improves Fontan circulation hemodynamics specifically in the setting of elevated pulmonary vascular resistance.
May support selective fenestration only in high-PVR Fontan but should not yet change practice; leaves open clinical validation.
Fenestration has been reported to enhance Fontan hemodynamics in several cases of Fontan circulation. However, the indication criteria for fenestration remain under discussion. To assess the effectiveness of fenestration in Fontan circulation, we conducted a theoretical analysis using a computational model of the fenestrated Fontan circulation. The cardiac chambers and vascular systems were modeled using the time-varying elastance model and the modified Windkessel model, respectively. When the pulmonary vascular resistance index was 4.01 Wood units m 2 , fenestration significantly reduced central venous pressure from 18.0 to 16.1 mmHg and decreased stressed blood volume from 610 to 555 ml. However, in the models with reduced ventricular end-systolic elastance, increased ventricular stiffness constant, or heightened systemic vascular resistance, the advantages of fenestration were diminished. Thus, fenestration may effectively improve the hemodynamics of Fontan circulation in patients with elevated pulmonary vascular resistance.
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Horio et al. (2024) studied this question.
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