Why the study?
Does a high salt diet cause structural vascular changes in normotensive rats?
Population
Adult male Sprague-Dawley rats
Comparison
2% NaCl diet for 3 or 6 months vs 0.7% NaCl diet
Design
Preclinical
Follow-up
3 or 6 months
Authors
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High-salt diet may induce preclinical vascular remodeling independent of BP in rats; hypothesis-generating and leaves open human translation.
Does a high salt diet cause structural vascular changes in normotensive rats?
A high salt diet induces structural vascular changes in normotensive rats, suggesting a mechanism by which salt may predispose to hypertension before blood pressure elevation occurs.
Géza Simon (2003) studied this question.
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