Why the study?
Does high-dose, weight-based FEIBA reduce time to INR < 1.5 in patients with warfarin-induced life-threatening bleeding compared to frozen plasma alone?
Population
48 patients with warfarin-induced life-threatening bleeds (matched 1:1 based on age and bleed location)
Comparison
High-dose, weight-based activated prothrombin… vs Frozen plasma alone
Design
Case-control
Authors
Loading...
May accelerate reversal in warfarin bleeding; hypothesis-generating pending randomized confirmation.
Does high-dose, weight-based FEIBA reduce time to INR < 1.5 in patients with warfarin-induced life-threatening bleeding compared to frozen plasma alone?
High-dose, weight-based FEIBA significantly reduces the time to INR reversal compared to frozen plasma alone in patients with warfarin-induced life-threatening bleeding, without a significant increase in thromboembolic events.
Messana et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: