Why the study?
Does four-factor prothrombin complex concentrate (4F-PCC) improve safety compared to plasma in patients requiring urgent vitamin K antagonist reversal?
Population
388 patients aged ≥ 18 years requiring rapid vitamin K antagonist reversal due to major bleeding or prior to…
Comparison
Four-factor prothrombin complex concentrate… vs Plasma dosed according to baseline INR and body…
Design
Meta-analysis, randomized
Follow-up
up to 45 days
Authors
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4F-PCC may be preferred over plasma for urgent VKA reversal to limit fluid overload; strengthens Level 1 meta-analytic safety data.
Does four-factor prothrombin complex concentrate (4F-PCC) improve safety compared to plasma in patients requiring urgent vitamin K antagonist reversal?
4F-PCC has a similar overall safety profile to plasma for urgent VKA reversal but is associated with fewer fluid overload events.
Milling et al. (2016) studied this question.
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