Many extracellular signals, tumor necrosis factor-a and interleukin-1 among them, transmit their signals to the genetic apparatus via the transcriptional activator, NF-kB. Maniatis summarizes what is known about this critical pathway and describes how two reports in this issue ([ Mercurio et al .][1] and [ Woronicz et al .][2]) add to the story. [1]: http://www.sciencemag.org/cgi/content/short/278/5339/860 [2]: http://www.sciencemag.org/cgi/content/short/278/5339/866
No takes yet. Share an insight, caveat, or question.
Tom Maniatis (1997) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: