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August 1, 1990Journal of Biological ChemistryOpen Access

Intracellular degradation of the transport-impaired human PiZ alpha 1-antitrypsin variant. Biochemical mapping of the degradative event among compartments of the secretory pathway.

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Authors

ALA. LeMichael E. DeBakey VA Medical CenterKGK. GrahamFlinders Medical CentreRSR N SifersBaylor College of Medicine

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Cite This Study

Le et al. (1990) studied this question.

synapsesocial.com/papers/6a7fb799e8dfc86a1cb8e5cfhttps://doi.org/10.1016/s0021-9258(18)77448-6
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Xenopus oocytes can synthesise but do not secrete the Z variant of human α1‐antitrypsin1984 · 61 citations
  2. 2ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES1985 · 4,885 citations
  3. 3Intracellular disruption of rat heart lysosomes by leucine methyl ester: effects on protein degradation.1981 · 39 citations
  4. 4Disruption of the 290–342 salt bridge is not responsible for the secretory defect of the PiZ α1-antitrypsin variant1989 · 54 citations