Why the study?
Does kidney-specific silencing of Erbb4-IR protect against diabetic kidney injury in db/db mice?
Population
db/db mice and in vitro mouse mesangial cells and mouse tubular epithelial cells
Comparison
Kidney-specific silencing of Erbb4-IR vs Control/unsilenced db/db mice and cells
Design
Preclinical
Authors
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Erbb4-IR emerges as a candidate target in diabetic nephropathy models; hypothesis-generating for human translation.
Does kidney-specific silencing of Erbb4-IR protect against diabetic kidney injury in db/db mice?
Erbb4-IR is a Smad3-dependent lncRNA that promotes renal fibrosis in type 2 diabetic nephropathy by suppressing miR-29b, suggesting it may be a novel therapeutic target.
Sun et al. (2017) studied this question.
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