Rising Trends in Cerebrovascular Disease and Substance Use-Related Mortality in the USA from 1999 to 2020: A Retrospective Analysis Using CDC WONDER

INTRODUCTION: Substance use (SU) has been linked to cerebrovascular disease due to numerous pathophysiologic alterations. This study discusses the age, race, and demographics-related trends in mortality among US adults (≥25 years) with concomitant SU and cerebrovascular disease. METHODS: The CDC WONDER database was used to access the mortality data. Age-adjusted mortality rates (AAMRs) per 100,000 population were calculated. Trends for age, sex, race, state, place of death, census region, and metropolitan status, along with annual percent change (APC) in AAMR, were calculated using the Joinpoint regression analysis. RESULTS: From 1999 to 2020, 57,838 deaths occurred, with an overall AAMR of 1.23. The highest AAMRs were observed in adults aged 45-64 (1.8), men (1.85), the non-Hispanic American Indian/Alaska Native population (3.23), the District of Columbia (2.78), and nonmetropolitan areas (1.35). CONCLUSION: The rising mortality related to SU and cerebrovascular disease with notable sociodemographic and temporal disparities calls for further research and early interventions.