This review highlights that the protein-coding region of enteroviral genomes contains RNA structures essential for viral replication and persistence.
May inform antiviral strategies against enteroviral persistence; leaves open clinical relevance in cardiac disease.
Enteroviruses are small RNA(+) viruses that encode one open reading frame flanked by two extensive noncoding regions carrying structural RNA regulatory elements that control replication and translation processes. For a long time the central, coding region was thought to remain single-stranded and its only function was supposed to be as the template for polyprotein synthesis. It turned out, however, that the protein coding region also encodes important RNA structures crucial for the viral life cycle and virus persistence in the host cells. This review considers the RNA structures in enteroviral genomes identified and characterized to date.
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Dutkiewicz et al. (2016) studied this question.
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