This review summarizes the pathogenesis of postoperative ileus after gastrointestinal surgery and discusses new therapies aimed at its prevention.
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Provides synthesis of ileus pathogenesis and therapies; leaves open need for randomized confirmation before practice change.
Postoperative ileus after gastrointestinal surgery results from many factors, including the effects of surgical trauma, anesthetic agents, hyperactivity of the sympathetic nervous system, local inflammatory reactions, and the use of opioids in the postoperative period. Postoperative ileus can lead to potential complications and may prolong patients' hospitalization, thereby leading to an increase in healthcare costs. There have been recent efforts to improve the understanding of the pathogenesis of postoperative ileus and to develop new treatments to prevent or minimize its occurrence. Here, we present a review of the factors related to the development of postoperative ileus and new therapies directed at its prevention.
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Maron et al. (2008) studied this question.
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