What question did this study set out to answer?

Determine which anthropometric obesity measure most accurately reflects beta-cell function and predicts incident type 2 diabetes among individuals with overweight or obesity.

February 8, 2025Annals of MedicineOpen Access

Waist-to-hip ratio better reflect beta-cell function and predicts diabetes risk in adult with overweight or obesity

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Why the study?

Controversy remains regarding which obesity measures better reflect beta-cell function and predict type 2 diabetes risk in overweight or obese individuals.

Does waist-to-hip ratio better reflect beta-cell function and predict type 2 diabetes risk compared to BMI, WC, and WHtR in adults with overweight or obesity?

Comparison

WHpR vs BMI, WC, and WHtR

Design

Cross-sectional study and prospective cohort study

Authors

NLNa LiuQingdao University BWBian WangTongji University GZGuanxiong ZhangCentral South University

Discussion

Member takes

Implication

May favor WHpR for earlier T2D risk detection in overweight patients; leaves open practice change given observational design.

Key Points

Determine which anthropometric obesity measure most accurately reflects beta-cell function and predicts incident type 2 diabetes among individuals with overweight or obesity.
Cross-sectional evaluation of 1,497 overweight or obese participants (median age 29 years, 41% males) assessed beta-cell function alongside BMI, waist circumference, waist-to-hip ratio, and waist-to-height ratio.
Prospective cohort validation in 322,023 UK Biobank participants without baseline diabetes (mean age 56.83 years, 50.4% males) to evaluate incident diabetes risk.
Waist-to-hip ratio demonstrated a stronger association with beta-cell function and central adiposity across all glucometabolic states compared to BMI, waist circumference, and waist-to-height ratio.
Waist-to-hip ratio significantly predicted incident type 2 diabetes risk (hazard ratio per SD increase: 2.311, 95% CI: 2.250–2.374).

Structured PICO

Does waist-to-hip ratio better reflect beta-cell function and predict type 2 diabetes risk compared to BMI, WC, and WHtR in adults with overweight or obesity?

Population

1,497 participants with overweight or obesity (median age 29 years, 41% males) from Xiangya Hospital, and 322,023 UK Biobank participants without diabetes at baseline (mean age 56.83 years, 50.4% males).

Intervention

Waist-to-hip ratio (WHpR)

Comparator

Body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR)

Outcome

Beta cell function indices and occurrence of diabeteshard clinical

Waist-to-hip ratio is superior to BMI, waist circumference, and waist-to-height ratio for estimating beta-cell function and predicting type 2 diabetes risk in overweight or obese individuals.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/6a7fbf32b407ef56284225cf https://doi.org/10.1080/07853890.2025.2462447

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Waist-to-hip ratio better reflect beta-cell function and predicts diabetes risk in adult with overweight or obesity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Waist-to-hip ratio better reflect beta-cell function and predicts diabetes risk in adult with overweight or obesity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider