Inhibitors of leukocyte adhesion have potential as antiphlogistics, antithrombotics, and immunosuppressants. The interaction of selectins and their membrane-bound carbohydrate ligands is decisive for the initial phase of adhesion, and the sialyl Lewisx group 1 is a common ligand for all three selectins. Thus the ingenious chemoenzymatic synthesis of 1 and its analogues reported recently by Paulson, Wong, et al. has received much attention.
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Athanassios Giannis (1994) studied this question.
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