The neural basis of weight control and obesity

According to the World Health Organization’s report, approximately 13% of the world’s adult population was obese, and 39% was overweight in 2016. The worldwide prevalence of obesity nearly tripled between 1975 and 2016 1 . Overconsumption of calorie-dense foods and a sedentary lifestyle are two main drivers of the global obesity epidemic. Despite obvious causes of obesity, our efforts to combat obesity have been unsuccessful. To effectively treat obesity, we need to understand how our body maintains a normal weight and what pathological processes disrupt weight control mechanisms.