Why the study?
Does simvastatin or lovastatin increase the risk of ischemic stroke or major hemorrhage compared to other statins in older patients taking dabigatran for atrial fibrillation?
Does simvastatin or lovastatin increase the risk of ischemic stroke or major hemorrhage compared to other statins in older patients taking dabigatran for atrial fibrillation?
In older patients taking dabigatran for atrial fibrillation, concurrent use of simvastatin or lovastatin is associated with a higher risk of major hemorrhage compared to other statins, suggesting alternative statins should be preferred.
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May warrant preferring other statins in older AF patients on dabigatran; leaves open causality and needs prospective confirmation.
Antoniou et al. (2016) studied this question.
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