Why the study?
Do non-vitamin K antagonist oral anticoagulants compared to warfarin reduce stroke/systemic embolism and major bleeding in patients with acute ischemic stroke or TIA and nonvalvular atrial fibrillation?
Population
1,137 Japanese patients with acute ischemic stroke or transient ischemic attack and nonvalvular atrial…
Comparison
Non-vitamin K antagonist oral anticoagulants… vs Warfarin initiated early after stroke/TIA onset.
Design
Cohort, not randomized
Follow-up
3 months
Authors
Loading...
NOACs show comparable safety to warfarin for early post-stroke anticoagulation in AF; hypothesis-generating and requires RCT confirmation.
Do non-vitamin K antagonist oral anticoagulants compared to warfarin reduce stroke/systemic embolism and major bleeding in patients with acute ischemic stroke or TIA and nonvalvular atrial fibrillation?
Early initiation of non-vitamin K antagonist oral anticoagulants after acute ischemic stroke or TIA in patients with nonvalvular atrial fibrillation appears safe and effective, with low rates of stroke and major bleeding comparable to warfarin.
Arihiro et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: