Population
Neonatal rat ventricular myocytes (NRVM)
Comparison
PI3K inhibitor LY-294002 vs Control / other compounds
Design
Preclinical
Authors
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May inform neonatal cardiomyocyte calcium handling mechanisms; leaves open therapeutic targeting of PI3K in human or adult cardiac disease.
PI3K regulates excitation-contraction coupling in neonatal cardiomyocytes primarily through modulation of L-type Ca2+ channel activity.
McDowell et al. (2004) studied this question.
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