Platelet Density and Size in Inflammatory Bowel Disease

OBJECTIVE: The present study investigates platelet density and mean platelet volume (MPV) in active inflammatory bowel disease (IBD). EXPERIMENTAL PROTOCOL: 27 patients with IBD (18 ulcerative colitis and 9 Crohn's disease) were compared to 12 healthy volunteers. 18 subjects had active disease. Platelet counts and mean platelet volume (MPV) were determined. Thereafter, platelets were separated according to density on a linear preformed Percoll gradient. A computerized device was employed for scanning transmission variations and thus the platelet distribution in the gradient and the platelet peak were identified. RESULTS AND CONCLUSIONS: Subjects with active IBD had greater platelet density (p = 0.02) and lower MPVs (p < 0.001). These findings may indicate augmented platelet granule content. The study also demonstrates that a low MPV is associated with active IBD.