Cardiovascular and Adenylate Cyclase Stimulant Properties of NKH477, a Novel Water-Soluble Forskolin Derivative

Anesthetized dogs and guinea pig ventricular membranes

NKH477 (intravenous injections 1-30 micrograms/kg, infusions 0.15-0.6 microgram/kg/min, intraduodenal 0.05-0.2 mg/kg, and oral 0.15 and 0.3 mg/kg)

Forskolin (for oral/intraduodenal activity and adenylate cyclase stimulation comparison)

Cardiovascular hemodynamic effects (left ventricular dP/dtmax, coronary and femoral artery blood flow, heart rate, myocardial oxygen consumption, blood pressure, cardiac output, total peripheral resistance) and adenylate cyclase stimulant activitysurrogate