What question did this study set out to answer?

To examine the duration, clearance patterns, and determinants of anal human papillomavirus (HPV) infection in a cohort of healthy women.

January 27, 2009Clinical Infectious DiseasesOpen Access

Duration and Clearance of Anal Human Papillomavirus (HPV) Infection among Women: The Hawaii HPV Cohort Study

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Authors

YSYurii B. ShvetsovUniversity of Hawaiʻi at Mānoa BHBrenda Y. HernandezCancer Center of Hawaii KMKatharine McDuffieUniversity of Hawaiʻi at Mānoa

Discussion

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Implication

Cohort study demonstrates rapid clearance of anal human papillomavirus infections in healthy women, suggesting limited efficacy of HPV testing for routine anal cancer screening.

Key Points

To examine the duration, clearance patterns, and determinants of anal human papillomavirus (HPV) infection in a cohort of healthy women.
Conducted a longitudinal cohort study of 431 sexually active women followed for an average duration of 1.2 years.
Obtained cervical and anal cell specimens for HPV DNA detection and conducted participant interviews at baseline and at 4-month intervals.
Among the 431 women, 50% developed 414 incident anal HPV infections, of which 58% cleared during follow-up.
High-risk anal HPV cleared at an incidence rate of 9.2 per 100 woman-months (95% CI, 6.9–11.9) with a median duration of 150 days (95% CI, 132–243 days); median clearance times were 132 days for HPV-16, 212 days for HPV-18, 252 days for HPV-58, and 350 days for HPV-59.
Anal intercourse, douching, and long-term tobacco smoking were nonviral risk factors significantly associated with delayed clearance of anal HPV.

Cite This Study

Shvetsov et al. (2009) studied this question.

synapsesocial.com/papers/6a7fd2ac40c9f484aa75e93a https://doi.org/10.1086/596758

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Implication

Cohort study demonstrates rapid clearance of anal human papillomavirus infections in healthy women, suggesting limited efficacy of HPV testing for routine anal cancer screening.

Duration and Clearance of Anal Human Papillomavirus (HPV) Infection among Women: The Hawaii HPV Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Duration and Clearance of Anal Human Papillomavirus (HPV) Infection among Women: The Hawaii HPV Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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