Why the study?
Does the presence of double genetic defects (factor V Leiden and G20210A prothrombin) increase the risk of recurrent DVT in patients following a first episode of DVT?
Population
259 patients following a first episode of deep venous thrombosis (DVT)
Comparison
Presence of genetic polymorphisms, specifically… vs Patients who were isolated heterozygous for…
Design
Cohort
Follow-up
786 patient-years
Authors
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Double defect may identify DVT patients for extended prophylaxis; leaves open whether routine genetic testing refines duration decisions.
Does the presence of double genetic defects (factor V Leiden and G20210A prothrombin) increase the risk of recurrent DVT in patients following a first episode of DVT?
Patients with a first DVT who lack proximal DVT and double genetic defects have a very low risk of recurrence (0.6% annual incidence), suggesting extended secondary thromboprophylaxis may not be necessary for this group.
González‐Porras et al. (2005) studied this question.
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