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January 1, 1999Thrombosis and Haemostasis

Coexistence of Factor V Leiden and Factor II A20210 Mutations and Recurrent Venous Thromboembolism

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Why the study?

Does the coexistence of Factor V Leiden and Factor II A20210 mutations increase the rate of recurrent venous thromboembolism in patients with deep venous thrombosis?

Population

542 patients with a documented diagnosis of deep venous thrombosis in one leg consecutively referred for a…

Comparison

Carriers of both Factor V Leiden and Factor II… vs Subjects carrying neither mutation, or carriers…

Design

Cohort

Discussion

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Implication

May identify high-risk DVT patients; leaves open whether genotyping should guide anticoagulation duration.

Structured PICO

Does the coexistence of Factor V Leiden and Factor II A20210 mutations increase the rate of recurrent venous thromboembolism in patients with deep venous thrombosis?

P
Population
542 patients with a documented diagnosis of deep venous thrombosis in one leg consecutively referred for a thrombophilic work-up
I
Intervention
Carriers of both Factor V Leiden and Factor II A20210 mutations
C
Comparator
Subjects carrying neither mutation, or carriers of only one mutation (Factor V Leiden or Factor II A20210)
O
Outcome
Rate of objectively documented previous recurrence of venous thromboembolismhard clinical

Patients carrying both Factor V Leiden and Factor II A20210 mutations have a significantly higher rate of recurrent venous thromboembolism, comparable to subjects with deficiencies of natural anticoagulant proteins.

Cite This Study

A 1999 study studied this question.

synapsesocial.com/papers/6a82492caedbb2834ec6aa14https://doi.org/10.1055/s-0037-1614882
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coexistence of Factor V G1691A and Factor II G20210A Gene Mutations in a Thrombotic Family Is Associated with Recurrence and Early Onset of Venous Thrombosis2001 · 10 citations
  2. 2Combined Effect of Factor V Leiden and Prothrombin 20210A on the Risk of Venous Thromboembolism2001 · 239 citations
  3. 3Venous Thrombosis with Both Heterozygous Factor V Leiden (R507Q) and Factor II (G20210A) Mutations2012 · 1 citations
  4. 4The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies2007 · 182 citations
  5. 5The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbs2013 · 9 citations