January 1, 2001Thrombosis and Haemostasis
Combined Effect of Factor V Leiden and Prothrombin 20210A on the Risk of Venous Thromboembolism
Key result
Double heterozygosity for Factor V Leiden and Factor II G20210A mutations was associated with a substantially increased risk of venous thromboembolism (OR 20.0; 95% CI 11.1-36.1).
Why the study?
Does the presence of both Factor V Leiden and Factor II G20210A mutations increase the risk of venous thromboembolism compared to controls?
Population
5,514 individuals from 8 pooled case-control studies.
Comparison
Presence of both Factor V Leiden and Factor II… vs Individuals without these mutations (controls)
Design
Meta-analysis
Authors
Discussion
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Implication
May inform family screening and prophylaxis decisions; confirms synergistic risk elevation but leaves optimal strategies open.
Study Design
Type
Meta-Analysis (n=5,514)
Multicenter
Yes
Structured PICO
Does the presence of both Factor V Leiden and Factor II G20210A mutations increase the risk of venous thromboembolism compared to controls?
P
Population
5,514 participants (2,310 cases and 3,204 controls) from a pooled analysis of 8 case-control studies evaluating genetic risk factors for venous thromboembolism.
E
Exposure
Presence of both Factor V Leiden and Factor II G20210A mutations (double heterozygotes)
C
Comparator
Individuals without these mutations (controls)
O
Outcome
Risk of venous thromboembolism (VTE)hard clinical
Main Result
Odds Ratio: 20 (95% CI 11.1–36.1)
Absolute Event Rate: 2.2% vs 0%
The combined presence of Factor V Leiden and Factor II G20210A mutations synergistically increases the risk of venous thromboembolism by 20-fold.
Cite This Study
Rosendaal et al. (2001) conducted a meta-analysis in Venous Thromboembolism (n=5,514). Double heterozygosity for Factor V Leiden and Factor II G20210A mutations vs. Controls without double heterozygosity was evaluated on Venous thromboembolism (OR 20.0, 95% CI 11.1-36.1). Double heterozygosity for Factor V Leiden and Factor II G20210A mutations was associated with a substantially increased risk of venous thromboembolism (OR 20.0; 95% CI 11.1-36.1).