September 27, 2004Archives of Internal Medicine
Prothrombin 20210A Mutation
Why the study?
Does the prothrombin 20210A mutation increase the risk of venous and arterial thrombotic events or pregnancy-related complications in first-degree relatives of affected patients?
Population
407 first-degree relatives of consecutive patients with the prothrombin 20210A mutation and a history of…
Comparison
Prothrombin 20210A mutation carrier status. vs Normal genotype (198 noncarriers).
Design
Cohort
Authors
Discussion
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Overview
Does not support routine screening of relatives; leaves open whether testing improves familial risk stratification.
Structured PICO
Does the prothrombin 20210A mutation increase the risk of venous and arterial thrombotic events or pregnancy-related complications in first-degree relatives of affected patients?
P
Population
407 first-degree relatives of consecutive patients with the prothrombin 20210A mutation and a history of venous thromboembolism (VTE) or premature atherosclerosis.
I
Intervention
Prothrombin 20210A mutation carrier status (204 heterozygous, 5 homozygous).
C
Comparator
Normal genotype (198 noncarriers).
O
Outcome
Incidences of first venous and arterial thrombotic events and pregnancy-related complications.hard clinical
The prothrombin 20210A mutation acts as a mild risk factor for VTE within families of carriers and may increase the risk of myocardial infarction, but does not significantly impact other arterial thrombotic diseases or pregnancy complications.
Cite This Study
Bank et al. (2004) studied this question.